Properties and precautions when using Bromhexine mucus-dissolving drug
Properties and precautions when using Bromhexine mucus-dissolving drug
When you have a cold, cough, sneeze, or produce a lot of phlegm, your doctor or pharmacist may recommend a mucolytic to help relieve your symptoms. Bromhexine is one of the most popular mucolytic medications.
Properties of Bromhexine
Bromhexine works by destroying the cell structure that produces mucus, making the mucus less viscous and making it easier to expel.
Bromhexine side effects
- Bloating or diarrhea
- Headache, nausea
- Sweating a lot
- sleepy
In addition to the minor side effects mentioned above, if you experience a rash, swelling of the face, mouth, or difficulty breathing like bronchospasm, you may be severely allergic to Bromhexine. Stop taking the drug and consult a specialist as soon as possible.
Precautions for using Bromhexine
- Should not be used for more than 14 consecutive days.
- Use only as directed by a doctor or pharmacist.
- People with stomach ulcers, asthma, liver disease, kidney disease should consult a doctor before using Bromhexine.
- Children, the elderly, and pregnant women should be careful when using this drug.
What is Bromhexine? What is Bromhexine used for?
1.1. Pharmacodynamics of the drug hydrochloride is a drug with expectorant effect. The reason is due to the ability to activate synthesis of sialomucin and break down mucopolysaccharide acid fibers, so the drug has the effect of making sputum more loose and less viscous. From โปรโมชั่น ufabet there, sputum from the bronchi easily escapes effectively. The active ingredient Bromhexine inhibits the human transmembrane serine receptor 2 (TMPRSS2). TMPRSS2 activation plays an important role in viral respiratory diseases such as influenza A and Middle East Respiratory Syndrome (MERS).
Inhibition of viral entry and receptor activation may be effective in the prevention and treatment of various respiratory diseases, including COVID-19 disease.
When taking it usually takes 2-3 days for patients to have clinical effects, but if injected, it only takes about 15 minutes.
1.2. Pharmacokinetics of the drug Absorption is rapidly absorbed from the gastrointestinal tract, due to its very strong first-pass metabolism in the liver, bioavailability when taken orally is only 20%. Food increases the bioavailability of Bromhexine. The drug concentration peaks in plasma after oral administration, from 1/2 hour to 1 hour.
Distribution is very widely distributed into body tissues. The drug has very strong binding ability (95-99%) to plasma proteins. When administered intravenously, the volume of distribution of the drug is about 7 liters/kg. The active substance crosses the blood-brain barrier and a small amount of the drug can cross the placenta.
